The
article ‘Determine a stems cell fate’ describes the new discoveries with what
happens to a stem cell at the molecular level that causes it to become one type
of cell and how does it become committed. Jingli A. Zhang led up the study
a graduate student in Rothenberg's lab.
The
researchers investigated the multipotent hematopoietic precursor cells to find
that all of the genes that play a role in transforming the precursor cells into
committed T cells, in the immune system. . Researchers also tracked genes that
could guide the precursor cells to various alternative pathways. The results
show when they become committed and how the T-cell-development process turned
off the genes promoting alternative fates.
Five
stages have been studied in the cascade of molecular events that yields a T
cell. Transcription factors are what they have identified during this process,
including many that code for regularity proteins which turn \ particular genes
on and off. The discoveries led to that during the second and third a
regulatory shift occurs when the T – cell commitment sets it. During this a lot
of transcription factors that activate genes associated with uncommitted stem
cells turn off while others that activate gene needed for future steps in T-
cell development.
A critical component that makes genes possible to be
expressed at a particular time is the expression of transcription- factor
genes. Parts of the genes are served as docking sights for the genes in
identifying the control sequences linked with certain regions of DNA as a
result of the action of transcription factors, affecting how hard or easy it is
for neighboring gene to be turned on or off. Rothenberg's
group has paved the way for researchers to identify control sequences for many
of the genes that turn on or off during T-cell development, by identifying DNA
regions where epigenetic markers are added or removed.
This
article relates to life and us because we are made up of cells. I thought that
this article also went well with the topic of us learning about the cell in
class.
I found
‘Determine a stems fate’ very interesting, before reading the article I didn’t
know anything of determinating the cells fate before reading this article.
"Determining a Stem Cell's Fate." Biology News
Net. California Institute of Technology, 12 Apr. 2012. Web. 17 Apr. 2012. <http://www.biologynews.net/archives/2012/04/12/determining_a_stem_cells_fate_.html>.
Emma summarized the article, “Determining a Stem Cell’s Fate,” well. She stated how Rothenberg’s research group has identified DNA areas where epigenetic markers were placed in or removed, which severely helped researchers recognize control sequences for a lot of genes that turn on or off during T-cell development. In addition, Emma clearly stated the purpose of this cell research, which is finding out what takes place to stem cells at the molecular level that leads them to become one type of cell, and how they become committed. Lastly, Emma wrote about the results of tracking genes that could guide precursor cells to a variety of other pathways, which is essential when speaking about an experiment.
ReplyDeleteAlthough Emma did a good job reviewing this article, there are many ways to improve it. First of all, Emma should have introduced who Ellen Rothenberg and Jingli A. Zhang are. Secondly, Emma should have had a better connection to this article. It is obvious and a well-known fact that humans are made up of cells. Also, Emma could have defined some biological terms that many students may not know or be familiar with. For example, she could have explained what multipotent hematopoietic precursor cells are.
The article, “Determining a Stem Cell’s Fate,” was a very confusing article. The language made it extremely difficult to comprehend. However, I did learn that a critical part that makes genes able to be expressed at a certain time is the expression of transcription- factor genes.
After reading this article by Emma, I think I can say there were definitely some interesting points made, and there were some confusing parts as well. For example, Emma did a good job of stating what the objective of this research done by Ellen Rothenburg and Jingli Zhang. This includes how these cells become a certain type of cell, by there molecular level, she wrote about how tracking genes could show precursor cells to different paths and she described how these T-cells become committed in the immune system.
ReplyDeleteDespite this review's positives, there were a few lacking aspects of the review. For instance, many of the terms in this review could've been defined further, since the reader may have a tough time following and understanding the review. Also, I didn't find the reason this research/experiment is important to be rather vague. I recommend a bit of elaboration on that part of the review.
From this review I learned about the stages cells go through to become T-cells. Even though it was hard to follow the review at times, I was still able to benefit from reading this review.
My classmate Emma reviewed the article, “Determining a Stem Cell’s Fate,” written by the Biology News Net writers. He review was great and I learned some new things that I had never knew before. I liked how Emma explained some of the actions that she mentioned in her review. This allowed me to better understand her review. Another thing i liked about Emma's review was that she relayed the main points to us clearly and in a tone that is easily understood. A last thing I liked about Emma's review was that she picked a great article given where we are in our curriculum right now.
ReplyDeleteAlthough I though Emma did a great job there were stills some things that I think she could've done better. For example she could've had more quotes in her review. Quotes make reviews easier to understand and it allows the reader to understand better. Another thing I thought she could've done better was that she could have mentioned more on how this connected to our lives as of today.
One thing I find unfathomable is how scientists can study and research stem cells. They are so small yet they are very important. I thought emma did a wonderful job reviewing.
My classmate, Emma Hutchings, did a good job summarizing her article on Stem Cells, written by www.biologynews.net. One thing that Emma did well in her article was get to the point. While many people prefer to fluff up their articles with meaningless information (myself included!), Emma gets straight to business on her explanation. A second things Emma did well was write with clarity. While I may have had a hard time understanding her points at times, Emma's clarity gave the article a flow, something that became essential in my understanding. A third thing that Emma did, though small, was limit her number of grammatical and spelling errors. This can be a huge deal when writing about something as complex as stem cell research.
ReplyDeleteWhile Emma took on an incredibly hard article, there were a couple things she could have improved upon - namely, the lack of explanation of terms. Yes, her writing had flow and lacked errors - but it also lacked some proper summarization. This made it somewhat heard to understand the topic Emma was trying to convey. A second thing that Emma could have improved upon was explaining the relevance of the article to our lives. Stem cells are very controversial, and have their supporters, but nothing of their impact on life was mentioned in Emma's summarization.
This was an incredibly hard article to review, but Emma went at it, and I'm glad to say I can come away from reading it feeling enlightened on the subject of stem cells, and their complexities. Emma did a pretty good job summarizing this difficult article.